Genetic variants associated with serum thyroid stimulating hormone (TSH) levels in European Americans and African Americans from the eMERGE Network. Academic Article uri icon

Overview

MeSH

  • Africa
  • Aged
  • Aged, 80 and over
  • Body Mass Index
  • Electronic Health Records
  • Europe
  • Female
  • Genome-Wide Association Study
  • Humans
  • Male
  • Middle Aged
  • Thyroid Diseases

MeSH Major

  • African Americans
  • European Continental Ancestry Group
  • Polymorphism, Single Nucleotide
  • Thyrotropin

abstract

  • Thyroid stimulating hormone (TSH) hormone levels are normally tightly regulated within an individual; thus, relatively small variations may indicate thyroid disease. Genome-wide association studies (GWAS) have identified variants in PDE8B and FOXE1 that are associated with TSH levels. However, prior studies lacked racial/ethnic diversity, limiting the generalization of these findings to individuals of non-European ethnicities. The Electronic Medical Records and Genomics (eMERGE) Network is a collaboration across institutions with biobanks linked to electronic medical records (EMRs). The eMERGE Network uses EMR-derived phenotypes to perform GWAS in diverse populations for a variety of phenotypes. In this report, we identified serum TSH levels from 4,501 European American and 351 African American euthyroid individuals in the eMERGE Network with existing GWAS data. Tests of association were performed using linear regression and adjusted for age, sex, body mass index (BMI), and principal components, assuming an additive genetic model. Our results replicate the known association of PDE8B with serum TSH levels in European Americans (rs2046045 p = 1.85×10-17, β = 0.09). FOXE1 variants, associated with hypothyroidism, were not genome-wide significant (rs10759944: p = 1.08×10-6, β = -0.05). No SNPs reached genome-wide significance in African Americans. However, multiple known associations with TSH levels in European ancestry were nominally significant in African Americans, including PDE8B (rs2046045 p = 0.03, β = -0.09), VEGFA (rs11755845 p = 0.01, β = -0.13), and NFIA (rs334699 p = 1.50×10-3, β = -0.17). We found little evidence that SNPs previously associated with other thyroid-related disorders were associated with serum TSH levels in this study. These results support the previously reported association between PDE8B and serum TSH levels in European Americans and emphasize the need for additional genetic studies in more diverse populations.

publication date

  • 2014

has subject area

  • Africa
  • African Americans
  • Aged
  • Aged, 80 and over
  • Body Mass Index
  • Electronic Health Records
  • Europe
  • European Continental Ancestry Group
  • Female
  • Genome-Wide Association Study
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Thyroid Diseases
  • Thyrotropin

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4249871

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0111301

PubMed ID

  • 25436638

Additional Document Info

start page

  • e111301

volume

  • 9

number

  • 12