A comparative encyclopedia of DNA elements in the mouse genome Academic Article uri icon

Overview

MeSH Major

  • Genome
  • Genomics
  • Mice
  • Molecular Sequence Annotation

abstract

  • The laboratory mouse shares the majority of its protein-coding genes with humans, making it the premier model organism in biomedical research, yet the two mammals differ in significant ways. To gain greater insights into both shared and species-specific transcriptional and cellular regulatory programs in the mouse, the Mouse ENCODE Consortium has mapped transcription, DNase I hypersensitivity, transcription factor binding, chromatin modifications and replication domains throughout the mouse genome in diverse cell and tissue types. By comparing with the human genome, we not only confirm substantial conservation in the newly annotated potential functional sequences, but also find a large degree of divergence of sequences involved in transcriptional regulation, chromatin state and higher order chromatin organization. Our results illuminate the wide range of evolutionary forces acting on genes and their regulatory regions, and provide a general resource for research into mammalian biology and mechanisms of human diseases.

authors

publication date

  • November 20, 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4266106

Digital Object Identifier (DOI)

  • 10.1038/nature13992

PubMed ID

  • 25409824

Additional Document Info

start page

  • 355

end page

  • 64

volume

  • 515

number

  • 7527