99mTc-labeled small-molecule inhibitors of prostate-specific membrane antigen: Pharmacokinetics and biodistribution studies in healthy subjects and patients with metastatic prostate cancer Academic Article uri icon

Overview

MeSH Major

  • Antigens, Surface
  • Gene Expression Regulation, Neoplastic
  • Glutamate Carboxypeptidase II
  • Organotechnetium Compounds
  • Prostatic Neoplasms
  • Technetium

abstract

  • Compared with the standard-of-care bone scanning, (99m)Tc-MIP-1404 and (99m)Tc-MIP-1405 identified most bone metastatic lesions and rapidly detected soft-tissue PCa lesions including subcentimeter lymph nodes. Because (99m)Tc-MIP-1404 has minimal activity in the bladder, further work is planned to correlate imaging findings with histopathology in patients with high-risk metastatic PCa.

publication date

  • January 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.2967/jnumed.114.140426

PubMed ID

  • 25342385

Additional Document Info

start page

  • 1791

end page

  • 8

volume

  • 55

number

  • 11