C16:0-ceramide signals insulin resistance Article uri icon

Overview

MeSH Major

  • Ceramides
  • Diet, High-Fat
  • Glucose Intolerance
  • Insulin Resistance
  • Sphingosine N-Acyltransferase

abstract

  • A substantive literature has accumulated implicating sphingolipids, in particular ceramides, as mediators of insulin resistance in metabolic syndrome. Thanks to recent technical advances in mouse genetics and lipidomics, two independent laboratories identify the same sphingolipid, C16:0-ceramide, as principal mediator of obesity-related insulin resistance (Turpin et al., 2014; Raichur et al., 2014).

publication date

  • January 2014

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.cmet.2014.10.017

Additional Document Info

start page

  • 703

end page

  • 5

volume

  • 20

number

  • 5