The effects of soy supplementation on gene expression in breast cancer: a randomized placebo-controlled study.
Carcinoma, Ductal, Breast
Receptor, Fibroblast Growth Factor, Type 2
Gene expression associated with soy intake and high plasma genistein defines a signature characterized by overexpression of FGFR2 and genes that drive cell cycle and proliferation pathways. These findings raise the concerns that in a subset of women soy could adversely affect gene expression in breast cancer.