Defining the role of common variation in the genomic and biological architecture of adult human height Review uri icon

Overview

MeSH Major

  • Body Height
  • European Continental Ancestry Group
  • Genetic Variation
  • Polymorphism, Single Nucleotide

abstract

  • Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/β-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.

authors

publication date

  • January 2014

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC4250049

Digital Object Identifier (DOI)

  • 10.1038/ng.3097

PubMed ID

  • 25282103

Additional Document Info

start page

  • 1173

end page

  • 86

volume

  • 46

number

  • 11