Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma Review uri icon

Overview

MeSH Major

  • European Continental Ancestry Group
  • Genetic Loci
  • Genetic Predisposition to Disease
  • Lymphoma, Large B-Cell, Diffuse

abstract

  • Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 × 10(-21)), rs2523607 at 6p21.33 (HLA-B; P = 2.40 × 10(-10)), rs79480871 at 2p23.3 (NCOA1; P = 4.23 × 10(-8)) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 × 10(-13) and 3.63 × 10(-11), respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.

authors

publication date

  • November 5, 2014

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC4213349

Digital Object Identifier (DOI)

  • 10.1038/ng.3105

PubMed ID

  • 25261932

Additional Document Info

start page

  • 1233

end page

  • 8

volume

  • 46

number

  • 11