Chronic myelogenous leukemia, version 1.2015 Academic Article uri icon

Overview

MeSH Major

  • Leukemia, Myeloid, Accelerated Phase
  • Leukemia, Myeloid, Chronic-Phase

abstract

  • Chronic myelogenous leukemia (CML) is usually diagnosed in the chronic phase. Untreated chronic phase CML will eventually progress to advanced phase (accelerated or blast phase) CML. Tyrosine kinase inhibitors (TKIs) have been shown to induce favorable response rates in patients with accelerated and blast phase CML. The addition of TKIs to chemotherapy has also been associated with improved outcomes in patients with blast phase CML. Allogeneic hematopoietic stem cell transplant remains a potentially curative option for patients with advanced phase CML, although treatment with a course of TKIs will be beneficial as a bridge to transplant. This manuscript discusses the recommendations outlined in the NCCN Guidelines for the diagnosis and management of patients with advanced phase CML.

publication date

  • January 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 25361806

Additional Document Info

start page

  • 1590

end page

  • 610

volume

  • 12

number

  • 11