Detecting the earliest signs of rheumatoid arthritis: Symptoms and examination Review uri icon

Overview

MeSH Major

  • Arthralgia
  • Arthritis, Rheumatoid
  • Joints
  • Range of Motion, Articular

abstract

  • Signs and symptoms often occur well in advance of a formal diagnosis of rheumatoid arthritis (RA). However, these do not necessarily represent symptoms that are included in classification criteria. Their intensity, frequency, and persistence over time seem to be important in the spectrum from preclinical autoimmunity to classifiable RA. Prospective study of signs and symptoms in individuals at risk for RA will help to determine their onset and relationship with epitope spreading, cytokine evolution, sensitive imaging, and their usefulness in discriminating between individuals patients who will develop incident inflammatory arthritis versus normal controls.

publication date

  • January 2014

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.rdc.2014.07.009

PubMed ID

  • 25437284

Additional Document Info

start page

  • 669

end page

  • 83

volume

  • 40

number

  • 4