The interplay between microRNAs and histone deacetylases in neurological diseases Review uri icon

Overview

MeSH Major

  • Histone Deacetylases
  • MicroRNAs
  • Nervous System Diseases

abstract

  • Neurological conditions, such as Alzheimer's disease and stroke, represent a prevalent group of devastating illnesses with few treatments. Each of these diseases or conditions is in part characterized by the dysregulation of many genes, including those that code for microRNAs (miRNAs) and histone deacetylases (HDACs). Recently, a complex relationship has been uncovered linking miRNAs and HDACs and their ability to regulate one another. This provides a new avenue for potential therapeutics as the ability to reinstate a careful balance between miRNA and HDACs has lead to improved outcomes in a number of in vitro and in vivo models of neurological conditions. In this review, we will discuss recent findings on the interplay between miRNAs and HDACs and its implications for pathogenesis and treatment of neurological conditions, including amyotrophic lateral sclerosis, Alzheimer's disease, Huntington's disease and stroke.

publication date

  • January 2014

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC4321688

Digital Object Identifier (DOI)

  • 10.1016/j.neuint.2014.03.012

PubMed ID

  • 24681158

Additional Document Info

start page

  • 33

end page

  • 9

volume

  • 77