Novel insights into the mitochondrial permeability transition Academic Article uri icon

Overview

MeSH Major

  • Mitochondrial Membrane Transport Proteins

abstract

  • Alavian and colleagues recently provided further evidence in support of the notion that the c subunit of the mitochondrial F1FO ATP synthase constitutes the long-sought pore-forming unit of the supramolecular complex responsible for the so-called 'mitochondrial permeability transition' (MPT). Besides shedding new light on the molecular mechanisms that underlie the MPT, these findings corroborate the notion that several components of the cell death machinery, including cytochrome c and the F1FO ATP synthase, mediate critical metabolic activities.

publication date

  • September 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4612113

Digital Object Identifier (DOI)

  • 10.4161/15384101.2014.949082

PubMed ID

  • 25486353

Additional Document Info

start page

  • 2666

end page

  • 70

volume

  • 13

number

  • 17