Polyclonal napsin a expression: A potential diagnostic pitfall in distinguishing primary from metastatic mucinous tumors in the lung Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma, Mucinous
  • Aspartic Acid Endopeptidases
  • Lung
  • Lung Neoplasms
  • Neoplasm Proteins

abstract

  • Napsin A shows decreased sensitivity and specificity for mucinous lung tumors and is unlikely to be reliable as a sole immunohistochemical marker of lung origin for such tumors (52% specificity in this study). The high frequency of napsin A expression in gastrointestinal mucinous tumors makes it particularly unreliable in distinguishing metastatic gastrointestinal from primary lung mucinous tumors. However, napsin A expression analysis may facilitate distinguishing mucinous tumors of pulmonary from those of nongastrointestinal origin. Interpretation of napsin A staining may be problematic in mucinous tumor specimens of low cellularity such as cell blocks.

publication date

  • January 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.5858/arpa.2013-0403-OA

PubMed ID

  • 25076295

Additional Document Info

start page

  • 1067

end page

  • 71

volume

  • 138

number

  • 8