Presumed assault or accommodative reactions involved in human renal transplantation Academic Article Article uri icon

Overview

MeSH Major

  • Lupus Erythematosus, Systemic
  • Nephritis
  • Renal Dialysis

abstract

  • The concept that allograft loss is secondary to immune assault mechanisms and graft success is simply due to abatement of such graft-destructive forces represents a reductive viewpoint of the complex immune processes that are involved in allograft rejection. The immunologically dominated fate of renal allografts appears to rest on the delicate balance between mutually opposing graft-destructive and graft-protective immune mechanisms unleashed by the host following the perception of potent stimulatory signals originated by the allograft. Activated cells and their secretory products, responsible for the irrevocable destruction of the allograft and immune circuits that are pivotal to the generation of graft-adaptive immune responses, are being rapidly identified. © 1984 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

publication date

  • January 1984

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.3109/08860228409115849

PubMed ID

  • 6400154

Additional Document Info

start page

  • 245

end page

  • 249

volume

  • 8

number

  • 3-4