Pathology and Diagnosis of Neuroendocrine Tumors: Lung Neuroendocrine Review uri icon

Overview

MeSH Major

  • Carcinoma, Large Cell
  • Carcinoma, Small Cell
  • Lung Neoplasms
  • Neuroendocrine Tumors

abstract

  • Neuroendocrine (NE) tumors of the lung include a spectrum from low-grade typical carcinoid (TC) and intermediate-grade atypical carcinoid (AC) to high-grade large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC). Although NE lung tumors are frequently discussed together, as in this article, carcinoids are very different from high-grade SCLC and LCNEC. SCLC and LCNEC are found in heavy-smoking, older patients, whereas smoking is not strongly associated with carcinoid tumors. On a molecular level, SCLC and LCNEC have extensive genetic abnormalities, but there are few in TC and slightly more in AC.

publication date

  • August 2014

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.thorsurg.2014.04.001

PubMed ID

  • 25065926

Additional Document Info

start page

  • 257

end page

  • 66

volume

  • 24

number

  • 3