Transcriptional diversity of long-term glioblastoma survivors Academic Article uri icon

Overview

MeSH Major

  • Brain Neoplasms
  • DNA Modification Methylases
  • DNA Repair Enzymes
  • Glioblastoma
  • Isocitrate Dehydrogenase
  • Mutation
  • Tumor Suppressor Proteins

abstract

  • While IDH mutant proneural tumors impart a better prognosis in the short-term, survival beyond 4 years does not require IDH mutation and is not dictated by a single transcriptional subclass. In contrast, MGMT methylation continues to have strong prognostic value for survival beyond 4 years. These findings have substantial impact for understanding GBM biology and progression.

publication date

  • January 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4136896

Digital Object Identifier (DOI)

  • 10.1093/neuonc/nou043

PubMed ID

  • 24662514

Additional Document Info

start page

  • 1186

end page

  • 95

volume

  • 16

number

  • 9