Transcriptional diversity of long-term glioblastoma survivors
DNA Modification Methylases
DNA Repair Enzymes
Tumor Suppressor Proteins
While IDH mutant proneural tumors impart a better prognosis in the short-term, survival beyond 4 years does not require IDH mutation and is not dictated by a single transcriptional subclass. In contrast, MGMT methylation continues to have strong prognostic value for survival beyond 4 years. These findings have substantial impact for understanding GBM biology and progression.