Cardiac responses to β-adrenoceptor stimulation is partly dependent on mitochondrial calcium uniporter activity Academic Article uri icon

Overview

MeSH Major

  • Calcium
  • Calcium Channels
  • Heart
  • Mitochondria, Heart
  • Receptors, Adrenergic, beta

abstract

  • Inhibition of the mitochondrial Ca(2+) uniporter decreases β-adrenoceptor response, uncoupling between workload and production of energetic metabolites. Our results support the hypothesis that the coupling of workload and energy supply is partly dependent on mitochondrial Ca(2+) uniporter activity.

publication date

  • January 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4241088

Digital Object Identifier (DOI)

  • 10.1111/bph.12684

PubMed ID

  • 24628066

Additional Document Info

start page

  • 4207

end page

  • 21

volume

  • 171

number

  • 18