Trial watch: Immunostimulatory cytokines in cancer therapy Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Cisplatin
  • Glutathione
  • Pyridoxal Kinase
  • Vitamin B 6

abstract

  • Tumor-targeting immune responses provide a significant contribution to (when they do not entirely account for) the clinical activity of diverse antineoplastic regimens, encompassing not only a large panel of immunotherapeutic strategies but also conventional cytotoxic molecules, targeted anticancer agents and irradiation. In line with this notion, several approaches have been devised to elicit novel or boost existing anticancer immune responses, including the administration of immunomodulatory cytokines. Such a relatively unspecific intervention suffices to mediate clinical effects in (at least a subset of) patients bearing particularly immunogenic tumors, like melanoma and renal cell carcinoma. More often, however, immunostimulatory cytokines are administered to boost the immunogenic potential of other agents, including (but not limited to) immune checkpoint-blocking antibodies, anticancer vaccines, oncolytic viruses and immunogenic chemotherapeutics. Here, we summarize the latest advances in the clinical development of recombinant cytokines as an immunomodulatory intervention for cancer therapy.

publication date

  • January 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4091551

Digital Object Identifier (DOI)

  • 10.4161/onci.29030

PubMed ID

  • 25083328

Additional Document Info

start page

  • e29030

volume

  • 3

number

  • 6