Virus-helminthcoinfection reveals a microbiota-independent mechanism of immunomodulation Academic Article uri icon


MeSH Major

  • Caliciviridae Infections
  • Coinfection
  • Gastroenteritis
  • Immunomodulation
  • Lectins
  • Microbiota
  • Norovirus
  • Trichinella
  • Trichinellosis
  • beta-N-Acetylhexosaminidases


  • The mammalian intestine is colonized by beneficial commensal bacteria and is a site of infection by pathogens, including helminth parasites. Helminths induce potent immunomodulatory effects, but whether these effects are mediated by direct regulation of host immunity or indirectly through eliciting changes in the microbiota is unknown. We tested this in the context of virus-helminth coinfection. Helminth coinfection resulted in impaired antiviral immunity and was associated with changes in the microbiota and STAT6-dependent helminth-induced alternative activation of macrophages. Notably, helminth-induced impairment of antiviral immunity was evident in germ-free mice, but neutralization of Ym1, a chitinase-like molecule that is associated with alternatively activated macrophages, could partially restore antiviral immunity. These data indicate that helminth-induced immunomodulation occurs independently of changes in the microbiota but is dependent on Ym1.

publication date

  • August 2014



  • Academic Article



  • eng

PubMed Central ID

  • PMC4548887

Digital Object Identifier (DOI)

  • 10.1126/science.1256942

PubMed ID

  • 25082704

Additional Document Info

start page

  • 578

end page

  • 82


  • 345


  • 6196