Recommendations on disease management for patients with advanced human epidermal growth factor receptor 2-positive breast cancer and brain metastases: American Society of Clinical Oncology clinical practice guideline Review uri icon


MeSH Major

  • Biomarkers, Tumor
  • Brain Neoplasms
  • Breast Neoplasms
  • Cranial Irradiation
  • Radiosurgery
  • Receptor, ErbB-2


  • Patients with brain metastases should receive appropriate local therapy and systemic therapy, if indicated. Local therapies include surgery, whole-brain radiotherapy, and stereotactic radiosurgery. Treatments depend on factors such as patient prognosis, presence of symptoms, resectability, number and size of metastases, prior therapy, and whether metastases are diffuse. Other options include systemic therapy, best supportive care, enrollment onto a clinical trial, and/or palliative care. Clinicians should not perform routine magnetic resonance imaging (MRI) to screen for brain metastases, but rather should have a low threshold for MRI of the brain because of the high incidence of brain metastases among patients with HER2-positive advanced breast cancer.

publication date

  • July 2014



  • Review



  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2013.54.0955

PubMed ID

  • 24799487

Additional Document Info

start page

  • 2100

end page

  • 8


  • 32


  • 19