Overcoming immunological barriers in regenerative medicine Academic Article uri icon


MeSH Major

  • Immune Tolerance
  • Regenerative Medicine


  • Regenerative therapies that use allogeneic cells are likely to encounter immunological barriers similar to those that occur with transplantation of solid organs and allogeneic hematopoietic stem cells (HSCs). Decades of experience in clinical transplantation hold valuable lessons for regenerative medicine, offering approaches for developing tolerance-induction treatments relevant to cell therapies. Outside the field of solid-organ and allogeneic HSC transplantation, new strategies are emerging for controlling the immune response, such as methods based on biomaterials or mimicry of antigen-specific peripheral tolerance. Novel biomaterials can alter the behavior of cells in tissue-engineered constructs and can blunt host immune responses to cells and biomaterial scaffolds. Approaches to suppress autoreactive immune cells may also be useful in regenerative medicine. The most innovative solutions will be developed through closer collaboration among stem cell biologists, transplantation immunologists and materials scientists.

publication date

  • January 2014



  • Academic Article



  • eng

PubMed Central ID

  • PMC4409427

Digital Object Identifier (DOI)

  • 10.1038/nbt.2960

PubMed ID

  • 25093888

Additional Document Info

start page

  • 786

end page

  • 94


  • 32


  • 8