Organelle-specific initiation of cell death Review uri icon


MeSH Major

  • Cell Death
  • Organelles


  • In a majority of pathophysiological settings, cell death is not accidental - it is controlled by a complex molecular apparatus. Such a system operates like a computer: it receives several inputs that inform on the current state of the cell and the extracellular microenvironment, integrates them and generates an output. Thus, depending on a network of signals generated at specific subcellular sites, cells can respond to stress by attemptinwg to recover homeostasis or by activating molecular cascades that lead to cell death by apoptosis or necrosis. Here, we discuss the mechanisms whereby cellular compartments - including the nucleus, mitochondria, plasma membrane, endoplasmic reticulum, Golgi apparatus, lysosomes, cytoskeleton and cytosol - sense homeostatic perturbations and translate them into a cell-death-initiating signal.

publication date

  • January 2014



  • Review



  • eng

Digital Object Identifier (DOI)

  • 10.1038/ncb3005

PubMed ID

  • 25082195

Additional Document Info

start page

  • 728

end page

  • 36


  • 16


  • 8