Racial disparities in the prevalence of monoclonal gammopathies: A population-based study of 12 482 persons from the national health and nutritional examination survey Academic Article uri icon


MeSH Major

  • Healthcare Disparities
  • Paraproteinemias


  • Multiple myeloma (MM) incidence is markedly higher in blacks compared with whites, which may be related to a higher prevalence of monoclonal gammopathy of undetermined significance (MGUS). Our objective was to define the prevalence and risk factors of MGUS in a large cohort representative of the US population. Stored serum samples from the National Health and Nutritional Examination Survey (NHANES) III or NHANES 1999-2004 were available for 12,482 individuals of age ⩾50 years (2331 'blacks', 2475 Hispanics, 7051 'whites' and 625 'others') on which agarose-gel electrophoresis, serum protein immunofixation, serum-free light-chain assay and M-protein typing were performed. MGUS was identified in 365 participants (2.4%). Adjusted prevalence of MGUS was significantly higher (P<0.001) in blacks (3.7%) compared with whites (2.3%) (P=0.001) or Hispanics (1.8%), as were characteristics that posed a greater risk of progression to MM. The adjusted prevalence of MGUS was 3.1% and 2.1% for the North/Midwest versus South/West regions of the United States, respectively (P=0.052). MGUS is significantly more common in blacks, and more often has features associated with higher risk of progression to MM. A strong geographic disparity in the prevalence of MGUS between the North/Midwest versus the South/West regions of the United States was found, which has etiologic implications.

publication date

  • January 2014



  • Academic Article



  • eng

PubMed Central ID

  • PMC4090286

Digital Object Identifier (DOI)

  • 10.1038/leu.2014.34

PubMed ID

  • 24441287

Additional Document Info

start page

  • 1537

end page

  • 42


  • 28


  • 7