Update on second primary malignancies in multiple myeloma: A focused review Review uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Multiple Myeloma
  • Neoplasms, Second Primary

abstract

  • The last decade has seen significant advances in the management of patients with multiple myeloma (MM). With increasingly effective therapies, MM patients are living longer. With improvements in survival, long-term complications including second primary malignancies are becoming new challenges in providing optimal care for MM patients. Three randomized studies have demonstrated possible clinical benefit with maintenance lenalidomide for patients with MM. These same studies have also demonstrated an increased risk of second primary malignancies. In this review, we will update on the current information regarding mechanisms and risk of developing second primary malignancies with a particular focus on disease- and treatment-related factors.

publication date

  • January 2014

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1038/leu.2014.22

PubMed ID

  • 24418993

Additional Document Info

start page

  • 1423

end page

  • 6

volume

  • 28

number

  • 7