Efficient acid-catalyzed 18F/19F fluoride exchange of BODIPY dyes Academic Article uri icon

Overview

MeSH Major

  • Acids
  • Boron Compounds
  • Fluorine

abstract

  • Fluorine-containing fluorochromes are important validation agents for positron emission tomography imaging compounds, as they can be readily validated in cells by fluorescence imaging. In particular, the (18) F-labeled BODIPY-FL fluorophore has emerged as an important platform, but little is known about alternative (18) F-labeling strategies or labeling on red-shifted fluorophores. In this study we explore acid-catalyzed (18) F/(19) F exchange on a range of commercially available N-hydroxysuccinimidyl ester and maleimide BODIPY fluorophores. We show this method to be a simple and efficient (18) F-labeling strategy for a diverse span of fluorescent compounds, including a BODIPY-modified PARP-1 inhibitor, and amine- and thiol-reactive BODIPY fluorophores.

publication date

  • January 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4145401

Digital Object Identifier (DOI)

  • 10.1002/cmdc.201300506

PubMed ID

  • 24596307

Additional Document Info

start page

  • 1368

end page

  • 73

volume

  • 9

number

  • 7