That's the "GIST" of it: Use of adjuvant imatinib after resection of a primary GI stromal tumor
Gastrointestinal Stromal Tumors
Protein Kinase Inhibitors
A 48-year-old man presented to his gastroenterologist with complaints of progressive dysphagia. The patient underwent an endoscopy that revealed a mass arising from the gastric fundus. Biopsies of the mass indicated an epithelioid tumor suggestive of a primary GI stromal sarcoma (GIST). A preoperative staging computed tomography/positron emission tomography scan disclosed a positron emission tomography-avid lesion in the stomach without sites of distant metastases. The patient underwent partial gastric resection with removal of a 7.8-cm primary GIST (Fig 1A) with 10 mitoses per 50 high-power fields (HPFs) that was negative for the kit protein (CD117). Mutational studies confirmed that the tumor was wild-type for c-kit but was also negative for PDGFRA and BRAF mutations. The patient presented for a discussion of adjuvant therapy. © 2014 by American Society of Clinical Oncology.
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