Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity Academic Article uri icon

Overview

MeSH Major

  • Adipocytes
  • Energy Intake
  • Fatty Acids
  • Leptin
  • Obesity
  • Peptide Hormones
  • Weight Loss

abstract

  • Spexin gene expression is markedly down-regulated in obese human fat. The peptide produces weight loss in DIO rodents. Its effects on appetite and energy regulation are presumably central; those on adipocyte FA uptake appear direct and peripheral. Spexin is a novel hormone involved in weight regulation, with potential for obesity therapy.

publication date

  • January 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4077920

Digital Object Identifier (DOI)

  • 10.1002/oby.20725

PubMed ID

  • 24550067

Additional Document Info

start page

  • 1643

end page

  • 52

volume

  • 22

number

  • 7