Recovery of consciousness is mediated by a network of discrete metastable activity states Academic Article uri icon

Overview

MeSH Major

  • Coma
  • Consciousness
  • Nerve Net

abstract

  • It is not clear how, after a large perturbation, the brain explores the vast space of potential neuronal activity states to recover those compatible with consciousness. Here, we analyze recovery from pharmacologically induced coma to show that neuronal activity en route to consciousness is confined to a low-dimensional subspace. In this subspace, neuronal activity forms discrete metastable states persistent on the scale of minutes. The network of transitions that links these metastable states is structured such that some states form hubs that connect groups of otherwise disconnected states. Although many paths through the network are possible, to ultimately enter the activity state compatible with consciousness, the brain must first pass through these hubs in an orderly fashion. This organization of metastable states, along with dramatic dimensionality reduction, significantly simplifies the task of sampling the parameter space to recover the state consistent with wakefulness on a physiologically relevant timescale.

publication date

  • June 24, 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4078822

Digital Object Identifier (DOI)

  • 10.1073/pnas.1408296111

PubMed ID

  • 24927558

Additional Document Info

start page

  • 9283

end page

  • 8

volume

  • 111

number

  • 25