Death-defining immune responses after apoptosis Review uri icon

Overview

MeSH Major

  • Apoptosis
  • Immunity, Innate
  • Infection
  • Inflammation
  • Organ Transplantation

abstract

  • Apoptosis is a programmed form of cell death whereby characteristic internal cellular dismantling is accompanied by the preservation of plasma membrane integrity. Maintaining this order during apoptosis prevents the release of cellular contents and ensures a noninflammatory death. Here, we consider examples of apoptosis in different contexts and discuss how the same form of cell death could have different immunological consequences. Multiple parameters such as cell death as a result of microbial infection, the nature of the inflammatory microenvironment, the type of responding phagocytic cells and the genetic background of the host organism all differentially influence the immunological consequences of apoptosis.

publication date

  • January 2014

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC4115279

Digital Object Identifier (DOI)

  • 10.1111/ajt.12736

PubMed ID

  • 24903539

Additional Document Info

start page

  • 1488

end page

  • 98

volume

  • 14

number

  • 7