Immune Thrombocytopenia Chapter uri icon

Overview

MeSH Major

  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Leukemia, Myeloid
  • Myelodysplastic Syndromes
  • Nuclear Proteins
  • Thrombocytopenia

abstract

  • Immune thrombocytopenia (ITP) is an autoimmune, acquired disease of adults and children characterized by transient or persistent thrombocytopenia. Variability in natural history and response to therapy suggests that primary ITP is heterogeneous from a clinical and pathophysiological point of view. Most cases are considered idiopathic or primary, whereas some are secondary to coexisting conditions. Certain of the cases which are secondary to autoimmune diseases or infections may be unapparent. Alternatively, underlying immune deficiencies may emerge. In addition, genetic factors may impact platelet turnover, propensity to bleed, and response to ITP-directed therapy. Here, we review the clinical and epidemiological features of children and adults with ITP. We then present an overview of the link between ITP and other autoimmune diseases or primary immunodeficiencies. Finally, we try to do an update on pathologic effector mechanisms of this complex autoimmune disease. © 2014 Elsevier Inc. All rights reserved.

publication date

  • December 2013

Research

keywords

  • Book Chapter

Identity

Digital Object Identifier (DOI)

  • 10.1016/B978-0-12-384929-8.00047-2

Additional Document Info

start page

  • 663

end page

  • 675