Anti-TCR mAb induces peripheral tolerance to alloantigens and delays islet allograft rejection in autoimmune diabetic NOD mice
Diabetes Mellitus, Experimental
Diabetes Mellitus, Type 1
Islets of Langerhans Transplantation
Receptors, Antigen, T-Cell
Overall, anti-TCR mAb induced peripheral tolerance to specific alloantigens even in the absence of Foxp3-expressing natural regulatory T cells. These findings reveal the potential for using TCR-targeting mAbs as induction immunotherapy for islet transplantation.