Anti-TCR mAb induces peripheral tolerance to alloantigens and delays islet allograft rejection in autoimmune diabetic NOD mice Academic Article uri icon

Overview

MeSH Major

  • Antibodies, Monoclonal
  • Diabetes Mellitus, Experimental
  • Diabetes Mellitus, Type 1
  • Graft Rejection
  • Graft Survival
  • Islets of Langerhans Transplantation
  • Isoantigens
  • Receptors, Antigen, T-Cell
  • Transplantation Tolerance

abstract

  • Overall, anti-TCR mAb induced peripheral tolerance to specific alloantigens even in the absence of Foxp3-expressing natural regulatory T cells. These findings reveal the potential for using TCR-targeting mAbs as induction immunotherapy for islet transplantation.

publication date

  • June 27, 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1097/TP.0000000000000120

PubMed ID

  • 24854475

Additional Document Info

start page

  • 1216

end page

  • 24

volume

  • 97

number

  • 12