Evidence-Based Recommendations for Fertility Preservation Options for Inclusion in Treatment Protocols for Pediatric and Adolescent Patients Diagnosed With Cancer Review uri icon


MeSH Major

  • Antineoplastic Agents
  • Fertility Preservation
  • Infertility
  • Neoplasms
  • Nursing Process


  • As survival rates improve for pediatric cancers, increased attention has been paid to late effects of cancer therapy, in particular, infertility. Fertility preservation options are available for pre- and postpubertal cancer patients; however, many providers lack knowledge regarding options. The aim of this article is to provide a comprehensive synthesis of current evidence and recommendations regarding fertility preservation options for children, adolescents, and young adults undergoing cancer treatment. A systematic search was performed to identify fertility preservation evidence. Fifty-three studies and 4 clinical guidelines were used for the review. Final recommendations consisted of 2 strong and 1 weak recommendation for both female and male fertility preservation options. The treatment team should be knowledgeable about fertility preservation so that they can educate patients and families about available fertility preservation options. It is important to consider and discuss all available fertility options with patients at the time of diagnosis.

publication date

  • January 2014



  • Review



  • eng

PubMed Central ID

  • PMC5213740

Digital Object Identifier (DOI)

  • 10.1177/1043454214532025

PubMed ID

  • 24799444

Additional Document Info

start page

  • 211

end page

  • 222


  • 31


  • 4