Impact of myeloid cells on the efficacy of anticancer chemotherapy Review uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Myeloid Cells
  • Neoplasms

abstract

  • Tumors are not immunologically silent but evolve and respond to therapy in the context of a continuous, bi-directional interaction with the host immune system. In line with this notion, several clinically successful chemotherapeutics have been shown to mediate antineoplastic effects as they (re)activate an anticancer immune response that is generally executed by lymphoid cells. Myeloid cells play a central role in this process, not only because they critically regulate the activity of T and B lymphocytes, but also because they exert direct tumoricidal effects, at least in some settings. Here, we discuss the impact of various myeloid cell populations, including macrophages, dendritic cells and myeloid-derived suppressor cells, on the efficacy of anticancer chemotherapy.

publication date

  • January 2014

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.coi.2014.05.009

PubMed ID

  • 24950501

Additional Document Info

start page

  • 24

end page

  • 31

volume

  • 30

number

  • 1