A monolithic passive check-valve for systematic control of temporal actuation in microfluidic devices
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Education, Medical, Graduate
This work describes the design and application of a microfluidic check-valve, made solely of poly(dimethylsiloxane), capable of passively controlling pressurized fluids. The integrated check-valve is designed to only allow forward-flow at certain threshold pressures and to negate both back-flow and diffusion when in a closed state. The required threshold pressures are directly related to the valve's geometry and therefore can be adjusted. We demonstrate that these valves are able to act simi-larly to a transistor and linked-up in a specific fashion to passively switch between simultaneously infused fluids. This shows the ability to create predefined passively controlled microfluidic systems. © 2008 CBMS.
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