Age-dependent neurovascular dysfunction and damage in a mouse model of cerebral amyloid angiopathy Academic Article uri icon

Overview

MeSH Major

  • Amyloid beta-Peptides
  • Cerebral Amyloid Angiopathy
  • Cerebrovascular Circulation
  • Somatosensory Cortex

abstract

  • Tg-SwDI mice exhibit a profound age-dependent cerebrovascular dysfunction, involving multiple regulatory mechanisms. Early in the disease process, oxidative stress is responsible for most of the vascular dysfunction, but with advancing disease structural alterations of the vasomotor apparatus also play a role. Early therapeutic interventions are likely to have the best chance to counteract the deleterious vascular effects of cerebral amyloid angiopathy.

publication date

  • January 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4284427

Digital Object Identifier (DOI)

  • 10.1161/STROKEAHA.114.005179

PubMed ID

  • 24781082

Additional Document Info

start page

  • 1815

end page

  • 21

volume

  • 45

number

  • 6