Microfluidic device and culture platform for the observation and control of axonal growth and axonal organelle transport of rat hippocampal neurons
Dipeptidyl-Peptidase IV Inhibitors
We report the design, fabrication, and implementation of a device to culture rat hippocampal neurons guided by arrays of cell-adhesive biopolymers on traditional cell culture substrates. These guided arrays of cells are shown to permit live-imaging of mitochondrial transport through the cell axon. We further report the development of a microfluidic device to deliver solutes to discrete sections of rat hippocampal neurons with spatial and temporal resolution. © 2009 CBMS.
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