Mitochondria in lung biology and pathology: more than just a powerhouse. Review uri icon

Overview

MeSH

  • Animals
  • Biological Markers
  • DNA Damage
  • DNA, Mitochondrial
  • Humans
  • Oxidative Stress
  • Oxygen
  • Reactive Oxygen Species
  • Respiratory Distress Syndrome, Adult

MeSH Major

  • Lung
  • Mitochondria

abstract

  • An explosion of new information about mitochondria reveals that their importance extends well beyond their time-honored function as the "powerhouse of the cell." In this Perspectives article, we summarize new evidence showing that mitochondria are at the center of a reactive oxygen species (ROS)-dependent pathway governing the response to hypoxia and to mitochondrial quality control. The potential role of the mitochondrial genome as a sentinel molecule governing cytotoxic responses of lung cells to ROS stress also is highlighted. Additional attention is devoted to the fate of damaged mitochondrial DNA relative to its involvement as a damage-associated molecular pattern driving adverse lung and systemic cell responses in severe illness or trauma. Finally, emerging strategies for replenishing normal populations of mitochondria after damage, either through promotion of mitochondrial biogenesis or via mitochondrial transfer, are discussed. Copyright © 2014 the American Physiological Society.

publication date

  • June 1, 2014

has subject area

  • Animals
  • Biological Markers
  • DNA Damage
  • DNA, Mitochondrial
  • Humans
  • Lung
  • Mitochondria
  • Oxidative Stress
  • Oxygen
  • Reactive Oxygen Species
  • Respiratory Distress Syndrome, Adult

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC4042189

Digital Object Identifier (DOI)

  • 10.1152/ajplung.00073.2014

PubMed ID

  • 24748601

Additional Document Info

start page

  • L962

end page

  • L974

volume

  • 306

number

  • 11