Involvement of autophagy in cervical, endometrial and ovarian cancer Review uri icon

Overview

MeSH Major

  • Autophagy
  • Endometrial Neoplasms
  • Ovarian Neoplasms
  • Uterine Cervical Neoplasms

abstract

  • Autophagy is an intracellular molecular pathway that maintains cellular homeostasis. A role for autophagy in the development as well as in the treatment of gynecologic malignancies, while still under-investigated, is receiving increased interest. Depending on concomitant factors, autophagy can either promote or suppress development of cervical, endometrial and ovarian cancer. Moreover, these cancer cells can utilize autophagy to promote its resistance to chemotherapeutic agents or, conversely, autophagy can enhance the efficacy of cytotoxic agents by promoting autophagic cell death. In this review the key autophagy-related mechanisms in development and treatment of cervical, endometrial and ovarian cancer are elucidated and evaluated.

publication date

  • August 2014

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/ijc.28524

PubMed ID

  • 24122662

Additional Document Info

start page

  • 519

end page

  • 28

volume

  • 135

number

  • 3