Proposed morphologic classification of prostate cancer with neuroendocrine differentiation Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma
  • Cell Differentiation
  • Neuroendocrine Tumors
  • Prostatic Neoplasms
  • Terminology as Topic

abstract

  • On July 31, 2013, the Prostate Cancer Foundation assembled a working committee on the molecular biology and pathologic classification of neuroendocrine (NE) differentiation in prostate cancer. New clinical and molecular data emerging from prostate cancers treated by contemporary androgen deprivation therapies, as well as primary lesions, have highlighted the need for refinement of diagnostic terminology to encompass the full spectrum of NE differentiation. The classification system consists of: Usual prostate adenocarcinoma with NE differentiation; 2) Adenocarcinoma with Paneth cell NE differentiation; 3) Carcinoid tumor; 4) Small cell carcinoma; 5) Large cell NE carcinoma; and 5) Mixed NE carcinoma - acinar adenocarcinoma. The article also highlights "prostate carcinoma with overlapping features of small cell carcinoma and acinar adenocarcinoma" and "castrate-resistant prostate cancer with small cell cancer-like clinical presentation". It is envisioned that specific criteria associated with the refined diagnostic terminology will lead to clinically relevant pathologic diagnoses that will stimulate further clinical and molecular investigation and identification of appropriate targeted therapies.

publication date

  • January 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4112087

Digital Object Identifier (DOI)

  • 10.1097/PAS.0000000000000208

PubMed ID

  • 24705311

Additional Document Info

start page

  • 756

end page

  • 67

volume

  • 38

number

  • 6