Multidimensional single-cell analysis of BCR signaling reveals proximal activation defect as a hallmark of chronic lymphocytic leukemia B cells Academic Article uri icon

Overview

MeSH Major

  • Gene Expression Regulation, Leukemic
  • Intracellular Signaling Peptides and Proteins
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Models, Statistical
  • Phospholipase C gamma
  • Protein-Tyrosine Kinases
  • Receptors, Antigen, B-Cell
  • Signal Transduction

abstract

  • Single-cell multidimensional analysis of BCR signaling permitted focused analysis of the variability and heterogeneity of signaling behavior from patient-to-patient, and from cell-to-cell. Disruption of the pSYK/pPLCγ2 relationship is uncovered as a robust hallmark of CLL B cell signaling behavior. Together, these observations implicate novel elements of the BCR signal transduction as potential therapeutic targets.

publication date

  • January 29, 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3906024

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0079987

PubMed ID

  • 24489640

Additional Document Info

start page

  • e79987

volume

  • 9

number

  • 1