Inflammatory bowel disease and celiac disease: Overlaps and differences Review uri icon

Overview

MeSH Major

  • Celiac Disease
  • Colitis, Ulcerative
  • Crohn Disease

abstract

  • Recent findings demonstrate the common genetic basis for many immune-mediated diseases, and consequently, the partially shared pathogenesis. We collected these findings and reviewed the extension of these overlaps to other disease characteristics. Two autoimmune diseases were selected that also share the specific target organ, the bowel. The etiology and immunopathogenesis of both conditions characterized by chronic intestinal inflammation, inflammatory bowel disease (IBD) and celiac disease (CeD), are not completely understood. Both are complex diseases with genetics and environment contributing to dysregulation of innate and adaptive immune responses, leading to chronic inflammation and disease. CeD constitutes a particular disease because the main environmental and genetic triggers are largely known. IBD comprises two main clinical forms, Crohn's disease and ulcerative colitis, which most likely involve a complex interplay between some components of the commensal microbiota and other environmental factors in their origin. These multifactorial diseases encompass a broad spectrum of clinical phenotypes and ages of onset, although the clinical presentation often differs depending on childhood or adult onset, with greater heterogeneity commonly observed in adults.

publication date

  • May 7, 2014

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC4009516

Digital Object Identifier (DOI)

  • 10.3748/wjg.v20.i17.4846

PubMed ID

  • 24803796

Additional Document Info

start page

  • 4846

end page

  • 56

volume

  • 20

number

  • 17