High proportion of patients with end-stage heart failure regardless of aetiology demonstrates anti-cardiac antibody deposition in failing myocardium: Humoral activation, a potential contributor of disease progression Academic Article uri icon

Overview

MeSH Major

  • Antibodies
  • Heart Failure
  • Myocardium

abstract

  • Evidence of anti-cardiac antibodies and complement activation was found in a large number of patients with end-stage cardiomyopathy regardless of the aetiology. Adenosine triphosphate synthase appears to be a new prominent antigenic stimulus; but more interestingly, the simultaneous co-existence of activated complement components suggests that this humoral mechanism may participate in disease progression.

publication date

  • April 21, 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1093/eurheartj/eht506

PubMed ID

  • 24375073

Additional Document Info

start page

  • 1061

end page

  • 8

volume

  • 35

number

  • 16