Hyaluronan synthase 3 variant and anthracycline-related cardiomyopathy: A report from the children's oncology group Academic Article uri icon

Overview

MeSH Major

  • Anthracyclines
  • Antibiotics, Antineoplastic
  • Cardiomyopathies
  • Glucuronosyltransferase
  • Polymorphism, Single Nucleotide

abstract

  • Hyaluronan (HA) produced by HAS3 is a ubiquitous component of the extracellular matrix and plays an active role in tissue remodeling. In addition, HA is known to reduce reactive oxygen species (ROS) -induced cardiac injury. The high cardiomyopathy risk associated with AA genotype could be due to inadequate remodeling and/or inadequate protection of the heart from ROS-mediated injury on high anthracycline exposure.

publication date

  • March 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3927733

Digital Object Identifier (DOI)

  • 10.1200/JCO.2013.50.3557

PubMed ID

  • 24470002

Additional Document Info

start page

  • 647

end page

  • 53

volume

  • 32

number

  • 7