Manipulation of the microbiota for treatment of IBS and IBD - Challenges and controversies Review uri icon


MeSH Major

  • Biological Therapy
  • Inflammatory Bowel Diseases
  • Intestines
  • Irritable Bowel Syndrome
  • Microbiota
  • Prebiotics
  • Probiotics


  • There is compelling rationale for manipulating the microbiota to treat inflammatory bowel diseases (IBDs). Although studies of animal models of intestinal inflammation produced promising results, trials in humans have been disappointing. In contrast to IBD, the role of the microbiota in the development of irritable bowel syndrome (IBS) only recently has been considered, but early stage results have been encouraging. As pharmaceutical companies develop fewer truly novel agents for treatment of these disorders, consumers seek safer, long-term strategies to deal with chronic symptoms. We assess the rationale for modulating the microbiota for treatment of IBD and IBS, and discuss whether current concepts are simplistic and overstated or simply under-researched. Are claims exaggerated and expectations unrealistic? Difficulties with microbiota terminology and technologies, as well as differences among patients and the heterogeneity of these diseases, pose additional challenges in developing microbiota-based therapies for IBD and IBS.

publication date

  • January 2014



  • Review



  • eng

Digital Object Identifier (DOI)

  • 10.1053/j.gastro.2014.01.050

PubMed ID

  • 24486051

Additional Document Info

start page

  • 1554

end page

  • 63


  • 146


  • 6