A prior diagnosis of breast cancer is a risk factor for breast cancer in brca1 and brca2 carriers Academic Article uri icon

Overview

MeSH Major

  • BRCA1 Protein
  • BRCA2 Protein
  • Biomarkers, Tumor
  • Breast Neoplasms
  • Gene Expression Regulation, Neoplastic
  • Genetic Testing
  • Mutation

abstract

  • In a woman with a BRCA1 or BRCA2 mutation who is diagnosed with breast cancer, the risk of cancer in the contralateral breast depends on the first diagnosis. That observation supports the hypothesis that there are important genetic or non-genetic modifiers of cancer risk in BRCA carriers. Discovering risk modifiers might lead to greater personalization of risk assessment and management recommendations for BRCA-positive patients.

publication date

  • January 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3997444

Digital Object Identifier (DOI)

  • 10.3747/co.21.1656

PubMed ID

  • 24764694

Additional Document Info

start page

  • 64

end page

  • 8

volume

  • 21

number

  • 2