Proteinase-activated receptors 1 and 2 and the regulation of porcine coronary artery contractility: A role for distinct tyrosine kinase pathways Academic Article uri icon

Overview

MeSH Major

  • Coronary Vessels
  • Protein-Tyrosine Kinases
  • Receptor, PAR-1
  • Receptor, PAR-2
  • Vasoconstriction

abstract

  • PAR1/2 -mediated contractions of the PCA are dependent on Src and MAPKinase and, in part, involve EGF-receptor-kinase transactivation and the generation of a COX-derived contractile agonist. However, the PYK signalling pathways used by PARs are distinct from each other and from those triggered by angiotensin-II and EGF. These signalling pathways may be therapeutic targets for managing coagulation-proteinase-induced coronary vasospasm.

publication date

  • January 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3997280

Digital Object Identifier (DOI)

  • 10.1111/bph.12593

PubMed ID

  • 24506284

Additional Document Info

start page

  • 2413

end page

  • 25

volume

  • 171

number

  • 9