Pharmacokinetics of a CCR5 inhibitor in rhesus macaques following vaginal, rectal and oral application Academic Article uri icon

Overview

MeSH Major

  • Anti-HIV Agents
  • CCR5 Receptor Antagonists
  • Pyrazoles
  • Receptors, HIV
  • Valine

abstract

  • The study provides clear evidence for vaginal-rectal and rectal-vaginal drug transfer pathways and suggests that oral pre-exposure prophylaxis with CMPD167 may be less efficacious at preventing sexual transmission of HIV-1 than topically applied products.

publication date

  • January 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3977607

Digital Object Identifier (DOI)

  • 10.1093/jac/dkt506

PubMed ID

  • 24381072

Additional Document Info

start page

  • 1325

end page

  • 9

volume

  • 69

number

  • 5