Systems approaches to human autoimmune diseases Review uri icon

Overview

MeSH Major

  • Autoimmune Diseases
  • Systems Biology

abstract

  • Systemic autoimmune diseases result from interactions between genes and environmental triggers that lead to dysregulation of both innate and adaptive immunity. Systems biology approaches enable the global characterization of complex systems at the DNA, RNA and protein levels. Recent technological breakthroughs such as deep sequencing or high-throughput proteomics are revealing novel inflammatory pathways involved in autoimmunity. Herein, we review recent developments, challenges and promising avenues in the use of systems approaches to understand human systemic autoimmune and autoinflammatory diseases.

publication date

  • October 2013

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3924714

Digital Object Identifier (DOI)

  • 10.1016/j.coi.2013.08.005

PubMed ID

  • 24055331

Additional Document Info

start page

  • 598

end page

  • 605

volume

  • 25

number

  • 5