Mesenchymal cell interaction with ovarian cancer cells induces a background dependent pro-metastatic transcriptomic profile Academic Article uri icon

Overview

MeSH Major

  • Cell Communication
  • Gene Expression Profiling
  • Mesenchymal Stromal Cells
  • Ovarian Neoplasms
  • Transcriptome

abstract

  • The contact with the mesenchymal niche increase metastatic initiation and expansion through cancer cells' transcriptome modification dependent of the cellular subtype. Personalized medicine strategy might benefit from network analysis revealing the subtype specific nodes to target to disrupt acquired pro-metastatic profile.

publication date

  • March 5, 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4132214

Digital Object Identifier (DOI)

  • 10.1186/1479-5876-12-59

PubMed ID

  • 24597747

Additional Document Info

start page

  • 59

volume

  • 12

number

  • 1