Primary thrombocytosis in children Review uri icon


MeSH Major

  • Thrombocythemia, Essential


  • Myeloproliferative neoplasms are uncommon disorders in children, for which we have limited understanding of the pathogenesis and optimal management. JAK2 and MPL mutations, while common drivers of myeloproliferative neoplasms in adult patients, are not clearly linked to pediatric disease. Management and clinical outcomes in adults have been well delineated with defined recommendations for risk stratification and treatment. This is not the case for pediatric patients, for whom there is neither a standard approach to workup nor any consensus regarding management. This review will discuss thrombocytosis in children, including causes of thrombocytosis in children, the limited knowledge we have regarding pediatric primary thrombocytosis, and our thoughts on potential risk stratification and management, and future questions to be answered by laboratory research and collaborative clinical study.

publication date

  • January 2014



  • Review



  • eng

PubMed Central ID

  • PMC3971071

Digital Object Identifier (DOI)

  • 10.3324/haematol.2013.092684

PubMed ID

  • 24688110

Additional Document Info

start page

  • 620

end page

  • 8


  • 99


  • 4