Prohibitin viral gene transfer protects hippocampal CA1 neurons from ischemia and ameliorates postischemic hippocampal dysfunction Academic Article uri icon

Overview

MeSH Major

  • CA1 Region, Hippocampal
  • Genetic Therapy
  • Ischemic Attack, Transient
  • Repressor Proteins

abstract

  • These data demonstrate that prohibitin overexpression protects highly vulnerable CA1 neurons from ischemic injury in vivo and suggest that the effect is mediated by reduction of postischemic reactive oxygen species generation and preservation of mitochondrial outer membrane integrity that prevents activation of apoptosis. Measures to enhance prohibitin expression could have translational value in ischemic brain injury and, possibly, other forms of brain injury associated with mitochondrial dysfunction.

publication date

  • January 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3971834

Digital Object Identifier (DOI)

  • 10.1161/STROKEAHA.113.003577

PubMed ID

  • 24619393

Additional Document Info

start page

  • 1131

end page

  • 8

volume

  • 45

number

  • 4